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Key Terms for Understanding the Human Microbiome:
Microbiome: a collection of genetic material from all the microbiota. The term was first used as it is defined today in 1988. It is used interchangeably with microbiota, even though there are subtle differences in the meaning of the terms.
Microbiota: a specific community of microorganisms found in a specific environment. The term has been in use for 50 years. Microbiota was formerly called microflora of the gut.
Microorganisms: any organism too small to be seen by the naked eye. Bacteria, viruses, fungi, and protozoa are microorganisms also called microbes.
Probiotics: live organisms, mostly bacteria, that directly add to the number of healthy microbiotas in the gut.
Prebiotics: non-digestible parts of foods that act like fertilizer to stimulate the growth of healthy bacteria in the gut.
The Human Microbiome is the genetic material of all the microbiota – bacteria, viruses, fungi, and protozoa present in the large intestine, skin, or body orifices.
The Human Microbiota refers to the trillions of microorganisms including bacteria, viruses, fungi, archaea, eukaryotes and protozoa.
Prebiotics vs. Probiotics
Prebiotics are the non-digestible part of foods (fiber) that are fermented in the large intestine. The fermentation of the fiber feeds beneficial bacteria and helps to increase their numbers. (Bananas, onions, garlic, Jerusalem artichoke, apple skins, and beans are examples of foods high in prebiotic fiber).
Probiotics differ from prebiotics in that they contain live organisms, mostly bacteria, that directly add to the number of healthy microbiotas in the gut (yogurt, sauerkraut, miso soup, and kimchi contain probiotics).
A symbiotic relationship
In a healthy person, these microbes coexist in a symbiotic relationship with their human host and confer to us a raft of benefits including aiding in digestion, helping with the absorption and production of essential nutrients, assisting our metabolism, and supporting our immune and nervous systems. However, if there is a disturbance in that balance our bodies may become more susceptible to disease.
Host-Gut Microbiota Interaction
An interplay between gut microbiota and host occurs mainly at the gastrointestinal mucosal barrier.
The host movements influence the composition and abundance of gut microbiota, whereas gut microbiota in turn modulate the metabolic and immunological activities of the host.
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