So, how is our microbiome formed?

Until recently it was commonly believed that our microbiome is first formed when we are born.

The first 1000 days

Illustration

Figure 1. (scroll down)

Heading photo

A mother's gift


During and after childbirth, bacteria from the mother’s gut take up residence in the baby’s body, seeding a unique community of beneficial bacteria that will help break down food, synthesize vitamins, and help teach the baby’s nascent immune system to recognize foreign organisms.
According to a new study Scientists at the Broad Institute of MIT and Harvard discovered that during pregnancy and the first year of life, some bacteria in the mother’s gut donate hundreds of genes to bacteria in the baby’s gut. 
Also, the baby's GM is impacted by maternal medications, stress, vaccinations, chemical exposures, diet, use of antibiotics, infection, host genetics., and perinatal exposures such as delivery mode, and perinatal medications [1] family lifestyle, geographic location.

Heading photo

Transitioning Milk to Solids


By the age of 36 months, the infant's gut microbiota develops into an adult-like gut microbiota, which is dominated by Firmicutes and Bacteroidetes phyla (this makeup>90% of the gut microbial population)[3]During the first few months of life, the primary source of nutrition is breast milk or formula. Therefore, the infant intestine at this stage favors the propagation of microbes such as Bifidobacterium that can ferment milk oligosaccharides. The introduction of solid food is a major contributor to the shift of the gut microbiome toward an adult-like structure, which was previously characterized by an increase of Bacteroidetes and the Firmicutes and a decrease in Actinobacteria and Proteobacteria phyla (Arrieta et al., 2014). The rationale behind this change is that the infant diet at this stage contains many polysaccharides that cannot be digested by their immature digestive system, thereby triggering an increase of the aforementioned microbes to facilitate this process. 
3. Ringel-Kulka et al., 2013; Voreades et al., 2014.

Heading photo

Adulthood changes


Overall, the adult microbiome remains relatively stable except following challenges such as infections, antibiotic treatment, or dietary changes. 
Even though our microbiome has the ability to recover over time, these challenges may subtly alter our unique microbial makeup.

Heading photo

 

As we age, it’s natural to lose some of the diversity in our gut microflora. 


For instance, Bifidobacteria are abundant in the infant microbiome and remain stable in adulthood. They then start to slowly decrease as the normal lifestyle changes associated with our golden years influence the composition of our microbiomes. These changes have been linked to increased risk of several chronic age-related diseases.

Figure 1 As shown in the figure, the maternal microbiota and the infant microbiota are affected by environmental and genetic factors. During pregnancy, the main influencing factors of the maternal microbiota are diet, use of antibiotics, infection, presence of microorganisms in the placenta, amniotic fluid, fetal membranes, cord blood of healthy pregnancies, stress, and host genetics. During delivery, the maternal microbiota will be transmitted vertically to the newborn, and the delivery mode and the gestational age of the newborn at birth affect the colonization of the newborn’s microbiota. The main influencing factors of infant microbiota are feeding mode, maternal diet, family lifestyle, geographic location, and host genetics. The window of opportunity for offspring microbiota modulation is pregnancy, delivery, infancy, and toddler.

Let's trace back to the beginnings of our microbiome.

You might also like

Illustration

What Should I Eat to keep my Brain Healthy

Eat these nutrient-dense foods before donating blood to prevent fatigue.

Illustration

What You Need to Know About Breast Cancer Screening

Guidelines recommend women get a mammogram every year beginning at age 40.

Illustration

5 Questions You Might be Too Embarrassed to Ask Your Gynecologist

Alex Khartchenko L. Lin, MD, a gynecologist at Northwestern Medicine, has the answers.

Data Deploy

Our company provides professional data employment for clients all over the world.

Business Consulting

Multipurpose assistance for online stores and offline retail businesses.